Description
Background: Protein phosphatase 2A subunit B isoform R2-alpha (PPP2R2A) is the component of regulatory subunit B of serine/threonine protein phosphatase 2A (PP2A). PPP2R2A belongs to the R2/B55/PR55 family of regulatory subunit B (1). Evidence suggests that subunit PPP2R2A enhances TGF-beta, Activin, and Nodal signaling pathways (7) and may play an important role in cell cycle regulation (2-4). PPP2R2A/PP2A, B55-alpha/PR55-alpha isoform interacts with the type I TGF-beta receptors via unique WD-40 repeats (5) that contribute to the anti-proliferative function of TGF-beta receptors (6)